The product of a thyroid hormone-responsive gene interacts with thyroid hormone receptors

The product of a thyroid hormone-responsive gene interacts with thyroid hormone receptors.

Thyroid hormone is a critical mediator of central nervous system (CNS) development, acting through nuclear receptors to modulate the expression of specific genes. Transcription of the rat hairless (hr) gene is highly up-regulated by thyroid hormone in the developing CNS; we show here that hr is directly induced by thyroid hormone. By identifying proteins that interact with the hr gene product (...

THRSP (thyroid hormone responsive).

Other names: LPGP1, Lpgp, MGC21659, S14, SPOT14 HGNC (Hugo): THRSP Location: 11q14.1 Local order: According to NCBI Map Viewer, genes flanking THRSP in centromere to telomere direction on 11q13 are: PHCA (11q13.5), phytoceramidase, alkaline; GDPD4 (11q13.5), glycerophosphate phosphodiesterase domain containing 4; PAK1 (11q13-14), p21/cdc42/Rac1-activated kinase1 (STE20 homolog, yeast); DFKZp434...

Mechanism of Action of the Thyroid Hormone on the Heart

SUMMARY  The foliowing cardiac effects may be at­tributed to thyroxin:  1-Thyroxin augments all anaerobic pro­cesses in the body includ::ng the heart, and decreases the glycogen content of the heart ( 1, 2, 5, 27). The resistance of the heart to anoxia is increased in hyperthyroidism ( 25). 2- Thyroxin influences the cardiac weight and prevents cardiac atrophy (3, 8, 10, 11, 19, 20, 21, 30...

Regulation of Gene Transcription by the Thyroid Hormone Receptors

Thyroid Stimulating Hormone Thyroid Stimulating Hormone